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Newly identified gene mutation explains why one family experiences unusual pain response to cold

If you’ve ever plunged your hand into a tub of ice water, you know about the overlap between cold and pain: That deep, biting ache makes you want to get your hand out of the water – fast. While the protective value of that sensation is obvious, scientists have always been a bit mystified by how pain-sensing nerves register cold temperatures. But now, Stanford research on a family with an extremely unusual gene mutation may help clarify what’s going on.

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Appetite for Life

Caitlin Burns was born with an immune deficiency and pseudo-obstruction of the gastrointestinal tract, a life-threatening condition that prevents the normal movement of food through her intestines. Packard specialists have been caring for her since she was an infant.