Jeff and MacKenzie Bezos Extend a $2.25 Million Challenge Grant to Fund Innovative Clinical Food Allergy Research at Stanford

Groundbreaking food allergy research at Stanford University School of Medicine and Lucile Packard Children’s Hospital Stanford has received a major boost through the creation of a challenge grant by Jeff and MacKenzie Bezos. Severe food allergies are a growing epidemic, with rates having doubled in the last decade. One out of every 13 children is affected, and over 30 percent are thought to have allergies to more than one food.

The donors have established a $2.25 million matching challenge grant to help change this reality. The goal is to raise a total of $4.5 million, which will help researchers to identify root causes and develop novel approaches, including immunotherapy. The university must close the challenge grant within a year’s time. Funding secured through the challenge will go toward the creation of an allergy research center at Stanford, led by Kari Nadeau, MD, PhD, an expert in the field of immunology, food allergies, and allergy immunotherapy, and an associate professor of pediatrics at Stanford University School of Medicine and Lucile Packard Children’s Hospital Stanford.

Under Nadeau’s leadership, a team at Stanford University School of Medicine and Lucile Packard Children’s Hospital Stanford has made several advances, detailed in a recent New York Times Magazine feature story. The team developed the first combination, multi-food-allergy therapy that has been shown to safely desensitize food-allergic patients to up to five different allergens at the same time. Clinical trial participants who were treated with combined immunotherapy successfully reached desensitization earlier than participants who did not use this combination regimen. Participants were gradually given small amounts of an allergen to build desensitization, along with the drug omalizumab, an anti-IgE drug that inhibits the protein that triggers allergic responses.

“Kari Nadeau and her colleagues are changing the paradigm for understanding and treating food allergies and offering so much hope to the growing number of children and families whose lives are impacted,” said Lloyd B. Minor, dean of Stanford University School of Medicine. “I am deeply grateful to Jeff and MacKenzie for their generosity and vision in supporting this innovative work.”

A dedicated allergy center on campus will enable Nadeau and her team to expand the number of clinical research studies and reach more patients through collaborations with other universities and hospitals across the country.

“Our food allergy studies that combine immunotherapy and omalizumab have shown promise for patients, with many reaching desensitization to their allergic foods in just six to nine months,” said Nadeau. “We hope that our continued clinical research studies, as well as collaboration with other hospitals, physicians, and researchers across the country, will allow us to gather more scientific data and results, potentially leading to an effective and insurable therapy for patients with food allergies throughout the world. This research depends on private donors who see the potential to impact millions of people. We are deeply grateful to Jeff and MacKenzie for making our research possible.”

“Dr. Nadeau and her team are transforming food allergy research,” said Jeff Bezos. “MacKenzie and I are optimistic that they will continue to achieve breakthroughs and improve the lives of allergy patients.”

About Allergy Research at Stanford
Thanks to the support of philanthropic leaders, Stanford University School of Medicine is establishing an interdisciplinary and interdependent allergy research center that makes transformative changes for patients and their families through innovative science, collaborative research, and compassionate care. The center will bring together top-ranked scientists, physician-scientists and research teams to focus on discovery-based allergy research. Moreover, the center aims to move beyond oral immunotherapy to make long-lasting changes in the field of allergy research, developing a lasting cure that leads to rapid induction of immune tolerance with excellent tolerability and little side effects. With a fully established allergy research center, Lucile Packard Children’s Hospital Stanford and Stanford University School of Medicine will help advance and ensure first-rate and timely progress in the field of allergy research and achieve the main goal of developing a lasting cure.

About the Lucile Packard Foundation for Children’s Health
The Lucile Packard Foundation for Children’s Health is a public charity, founded in 1997. Its mission is to elevate the priority of children’s health, and to increase the quality and accessibility of children’s health care through leadership and direct investment. The Foundation directs all fundraising for Lucile Packard Children’s Hospital Stanford and the child health programs of Stanford University School of Medicine.